Independent Generation and Reactivity of 2'-Deoxyguanosin-N1-yl Radical.

ABSTRACT: 2'-Deoxyguanosin-N1-yl radical (dG(N₁-H)^•) is the thermodynamically favored one-electron oxidation product of 2'-deoxyguanosine (dG), the most readily oxidized native nucleoside. dG(N₁-H)^• is produced by the formal dehydration of a hydroxyl radical adduct of dG as well as by deprotonation of the corresponding radical cation. dG(N₁-H)^• were formed as a result of the indirect and direct effects of ionizing radiation, among other DNA damaging agents. dG(N₁-H)^• was generated photochemically (λ_max = 350 nm) from an N-aryloxy-naphthalimide precursor (3). The quantum yield for photochemical conversion of 3 is ∼0.03 and decreases significantly i

SUBMITTER: Zheng L 

PROVIDER: S-EPMC7334105 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature