Ontology highlight
ABSTRACT:
SUBMITTER: Liang T
PROVIDER: S-EPMC7334576 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Liang Tuo T Qian Zhong-Ming ZM Mu Ming-Dao MD Yung Wing-Ho WH Ke Ya Y
iScience 20200619 7
Despite intensive research on Parkinson disease (PD) for decades, this common neurodegenerative disease remains incurable. We hypothesize that abnormal iron accumulation is a common thread underlying the emergence of the hallmarks of PD, namely mitochondrial dysfunction and α-synuclein accumulation. We investigated the powerful action of the main iron regulator hepcidin in the brain. In both the rotenone and 6-hydroxydopamine models of PD, overexpression of hepcidin by means of a virus-based str ...[more]