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Improving protein solubility and activity by introducing small peptide tags designed with machine learning models.


ABSTRACT: Highlights•Short tags were added to proteins to improve their protein solubility.•Machine learning model was used to optimize amino acid composition of the tags.•Multiple proteins’ solubility was substantially improved.•Catalytic activity of one enzyme was increased when its solubility was enhanced.

SUBMITTER: Han X 

PROVIDER: S-EPMC7334598 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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