Ontology highlight
ABSTRACT:
SUBMITTER: Mukadam IZ
PROVIDER: S-EPMC7334833 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Mukadam Insiya Z IZ Machhi Jatin J Herskovitz Jonathan J Hasan Mahmudul M Oleynikov Maxim D MD Blomberg Wilson R WR Svechkarev Denis D Mohs Aaron M AM Zhou You Y Dash Prasanta P McMillan JoEllyn J Gorantla Santhi S Garrison Jered J Gendelman Howard E HE Kevadiya Bhavesh D BD
Biomaterials 20191207
Antiretroviral therapy (ART) has improved the quality and duration of life for people living with human immunodeficiency virus (HIV) infection. However, limitations in drug efficacy, emergence of viral mutations and the paucity of cell-tissue targeting remain. We posit that to maximize ART potency and therapeutic outcomes newer drug formulations that reach HIV cellular reservoirs need be created. In a step towards achieving this goal we harnessed the aggregation-induced emission (AIE) property o ...[more]