Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YD
PROVIDER: S-EPMC7335068 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Zhang Yan Dora YD Hurson Amber N AN Zhang Haoyu H Choudhury Parichoy Pal PP Easton Douglas F DF Milne Roger L RL Simard Jacques J Hall Per P Michailidou Kyriaki K Dennis Joe J Schmidt Marjanka K MK Chang-Claude Jenny J Gharahkhani Puya P Whiteman David D Campbell Peter T PT Hoffmeister Michael M Jenkins Mark M Peters Ulrike U Hsu Li L Gruber Stephen B SB Casey Graham G Schmit Stephanie L SL O'Mara Tracy A TA Spurdle Amanda B AB Thompson Deborah J DJ Tomlinson Ian I De Vivo Immaculata I Landi Maria Teresa MT Law Matthew H MH Iles Mark M MM Demenais Florence F Kumar Rajiv R MacGregor Stuart S Bishop D Timothy DT Ward Sarah V SV Bondy Melissa L ML Houlston Richard R Wiencke John K JK Melin Beatrice B Barnholtz-Sloan Jill J Kinnersley Ben B Wrensch Margaret R MR Amos Christopher I CI Hung Rayjean J RJ Brennan Paul P McKay James J Caporaso Neil E NE Berndt Sonja I SI Birmann Brenda M BM Camp Nicola J NJ Kraft Peter P Rothman Nathaniel N Slager Susan L SL Berchuck Andrew A Pharoah Paul D P PDP Sellers Thomas A TA Gayther Simon A SA Pearce Celeste L CL Goode Ellen L EL Schildkraut Joellen M JM Moysich Kirsten B KB Amundadottir Laufey T LT Jacobs Eric J EJ Klein Alison P AP Petersen Gloria M GM Risch Harvey A HA Stolzenberg-Solomon Rachel Z RZ Wolpin Brian M BM Li Donghui D Eeles Rosalind A RA Haiman Christopher A CA Kote-Jarai Zsofia Z Schumacher Fredrick R FR Al Olama Ali Amin AA Purdue Mark P MP Scelo Ghislaine G Dalgaard Marlene D MD Greene Mark H MH Grotmol Tom T Kanetsky Peter A PA McGlynn Katherine A KA Nathanson Katherine L KL Turnbull Clare C Wiklund Fredrik F Chanock Stephen J SJ Chatterjee Nilanjan N Garcia-Closas Montserrat M
Nature communications 20200703 1
Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of polygenicity, involving at a minimum of thousands of loci. We project that sample si ...[more]