Ontology highlight
ABSTRACT:
SUBMITTER: Castanon I
PROVIDER: S-EPMC7335183 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Castanon I I Hannich J T JT Abrami L L Huber F F Dubois M M Müller M M van der Goot F G FG Gonzalez-Gaitan M M
Nature communications 20200703 1
Oriented cell division is a fundamental mechanism to control asymmetric stem cell division, neural tube elongation and body axis extension, among other processes. During zebrafish gastrulation, when the body axis extends, dorsal epiblast cells display divisions that are robustly oriented along the animal-vegetal embryonic axis. Here, we use a combination of lipidomics, metabolic tracer analysis and quantitative image analysis to show that sphingolipids mediate spindle positioning during oriented ...[more]