Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC7335350 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Li Marina M Lin Cindy C Deng Hui H Strnad Joann J Bernabei Luca L Vogl Dan T DT Burke James J JJ Nefedova Yulia Y
Molecular cancer therapeutics 20200505 7
Multiple myeloma is a plasma cell malignancy, which grows in the bone marrow (BM). The major population of cells in the BM is represented by neutrophils and they can form neutrophil extracellular traps (NET). Here, we investigated whether multiple myeloma cells induce NET formation and whether targeting this process would delay multiple myeloma progression. We demonstrated that murine and human multiple myeloma cells stimulate citrullination of histone H3 and NET formation by neutrophils and tha ...[more]