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Notified dengue deaths in Myanmar (2017-18): profile and diagnosis delays.

ABSTRACT: Background: Complications in dengue usually occur between day four and day six after fever onset. Hence, early diagnosis and haematological monitoring are vital. Among all hospital reported dengue deaths in Myanmar in 2017-18, we assessed the i) patient profile, ii) proportion of patients who arrived with a dengue diagnosis at admission and iii) delays in diagnosis after fever onset. Methods: This was a descriptive study involving secondary data. For all the notified deaths, death investigation forms were not available in prescribed format and therefore, data were extracted from hospital case records. Results: Of 304 deaths, 184 (60.5%) were female and 233 (76.6%) were less than 10 years old. Township level hospitals or below reported 36 deaths (11.8%) and the remaining deaths were from higher level facilities. Dengue was diagnosed before admission in 26 (8.5%) people and 169 (55.6%) were in shock at admission. Of 208 with date of fever onset recorded, the median diagnosis delay was four (interquartile range-IQR: 3, 5) days. Patient level delay (median three days) was a major contributor to the diagnosis delay. Conclusions: Most of the patients who died did not have a diagnosis of dengue before admission. This calls for an urgent review of health system preparedness in peripheral health facilities to suspect, diagnose, monitor, refer and treat dengue in children and patient level factors for better understanding of the reasons of delay. Timely filling of death investigation forms in a prescribed format and quarterly death reviews based on these is recommended.

SUBMITTER: Linn NN

PROVIDER: S-EPMC7336047 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Notified dengue deaths in Myanmar (2017-18): profile and diagnosis delays.

Linn Nwe Ni NN Kyaw Khine Wut Yee KWY Shewade Hemant Deepak HD Kyaw Aye Mon Mon AMM Tun Myat Min MM Khine San Kyawt SK Linn Nay Yi Yi NYY Thi Aung A Lin Zaw Z

F1000Research 20200609

<b>Background:</b> Complications in dengue usually occur between day four and day six after fever onset. Hence, early diagnosis and haematological monitoring are vital. Among all hospital reported dengue deaths in Myanmar in 2017-18, we assessed the i) patient profile, ii) proportion of patients who arrived with a dengue diagnosis at admission and iii) delays in diagnosis after fever onset. <b>Methods:</b> This was a descriptive study involving secondary data. For all the notified deaths, death ...[more]

PMID: 32724563

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Project description:BackgroundThe recent situation of dengue infection in Cirebon district is concerning due to an upsurge trend since the year 2010. The largest dengue outbreak was reported in 2016 which has affected more than 1600 children. A study was conducted to explore the temporal variability of dengue outbreak in Cirebon's child population in during 2011-2017, and to assess the short-term effects of climatic and environmental factor on dengue incidence. In addition, the spatial pattern of dengue incidence in children and high-risk villages were investigated.MethodsA total of 4597 confirmed dengue cases in children notified from January 2011 to December 2017 were analysed. Seasonal decomposition analysis was carried out to examine the annual seasonality. A generalized linear model (GLM) was applied to assess the short-term effect of climate and normalized difference vegetation index (NDVI) on dengue incidence. The incidence rate ratio (IRR) of the final model was reported. Spatial analyses were conducted by using Moran's I and local indicator of spatial association (LISA) analyses to explore geographical clustering in incidence and to identify high-risk villages for dengue, respectively.ResultsAn annual dengue epidemic period was observed with peaks occurring every January/February. Based on the GLM, temperature at a lag 4 months (IRR = 1.27; 95% confidence interval, 95% CI: 1.22-1.31, P < 0.001), rainfall at a lag 2 months (IRR = 0.99, 95% CI: 0.99-0.99, P < 0.001), humidity at lag 0 month (IRR = 1.05, 95% CI: 1.04-1.06, P < 0.001) and NDVI at a lag 1 month (IRR = 3.07, 95% CI: 1.94-4.86, P < 0.001) were associated with dengue incidence in children. The dengue incidence in children was spatially varied and clustered at the village level across Cirebon. During 2011-2017, a total of 38 high-risk villages for dengue were identified, which were mainly located in the northern part of Cirebon.ConclusionsSeasonal patterns of dengue incidence in children in Cirebon were strongly associated with rainfall, temperature, humidity and NDVI variability, suggesting that climatic and environmental data could be used to help predict dengue outbreaks. Our spatial analysis revealed a clustered pattern in dengue incidence and high-risk villages for dengue across Cirebon, suggesting that effective interventions such as vector surveillance and school-based campaigns should be prioritized around the identified high-risk villages. Temporal and spatial analytical tools could be utilized to support local health authorities to apply timely and targeted public health interventions and help better planning and decision-making in order to minimize the impact of dengue outbreaks.

Dataset Information

Notified dengue deaths in Myanmar (2017-18): profile and diagnosis delays.

Publications

Notified dengue deaths in Myanmar (2017-18): profile and diagnosis delays.

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