SIRT1-NOX4 signaling axis regulates cancer cachexia.
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ABSTRACT:
SUBMITTER: Dasgupta A
PROVIDER: S-EPMC7336299 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
SIRT1-NOX4 signaling axis regulates cancer cachexia.
Dasgupta Aneesha A Shukla Surendra K SK Vernucci Enza E King Ryan J RJ Abrego Jaime J Mulder Scott E SE Mullen Nicholas J NJ Graves Gavin G Buettner Kyla K Thakur Ravi R Murthy Divya D Attri Kuldeep S KS Wang Dezhen D Chaika Nina V NV Pacheco Camila G CG Rai Ibha I Engle Dannielle D DD Grandgenett Paul M PM Punsoni Michael M Reames Bradley N BN Teoh-Fitzgerald Melissa M Oberley-Deegan Rebecca R Yu Fang F Klute Kelsey A KA Hollingsworth Michael A MA Zimmerman Matthew C MC Mehla Kamiya K Sadoshima Junichi J Tuveson David A DA Singh Pankaj K PK
The Journal of experimental medicine 20200701 7
Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic interventions remain poorly studied. We observed a significant positive correlation between SIRT1 expression and muscle fiber cross-sectional area in pancreatic cancer patients. Rescuing Sirt1 expression by exogenous expression or pharmacological agents reverted cancer cell-induced myotube wasting in culture conditions and mouse models. RNA-seq ...[more]
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