Ontology highlight
ABSTRACT:
SUBMITTER: Dasgupta A
PROVIDER: S-EPMC7336299 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200701 7
Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic interventions remain poorly studied. We observed a significant positive correlation between SIRT1 expression and muscle fiber cross-sectional area in pancreatic cancer patients. Rescuing Sirt1 expression by exogenous expression or pharmacological agents reverted cancer cell-induced myotube wasting in culture conditions and mouse models. RNA-seq ...[more]