Ontology highlight
ABSTRACT:
SUBMITTER: Toboso-Navasa A
PROVIDER: S-EPMC7336312 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200701 7
Memory B cells (MBCs) are key for protection from reinfection. However, it is mechanistically unclear how germinal center (GC) B cells differentiate into MBCs. MYC is transiently induced in cells fated for GC expansion and plasma cell (PC) formation, so-called positively selected GC B cells. We found that these cells coexpressed MYC and MIZ1 (MYC-interacting zinc-finger protein 1 [ZBTB17]). MYC and MIZ1 are transcriptional activators; however, they form a transcriptional repressor complex that r ...[more]