Targeting the innate immune receptor TLR8 using small-molecule agents.
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ABSTRACT:
SUBMITTER: Sakaniwa K
PROVIDER: S-EPMC7336380 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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Targeting the innate immune receptor TLR8 using small-molecule agents.
Sakaniwa Kentaro K Shimizu Toshiyuki T
Acta crystallographica. Section D, Structural biology 20200617 Pt 7
Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) recognizes single-stranded RNA to mediate downstream signals. In recent years, intensive X-ray crystal structural analyses have provided atomic insights into structures of TLR8 complexed with various agonists or antagonists. Here, structural knowledge of the activation and inactivation mechanisms of the ligands is reviewed. In addition, the potential clinical applic ...[more]
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