Ontology highlight
ABSTRACT:
SUBMITTER: Trychta KA
PROVIDER: S-EPMC7336508 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Trychta Kathleen A KA Bäck Susanne S Henderson Mark J MJ Harvey Brandon K BK
Cell reports 20181101 7
Retention of critical endoplasmic reticulum (ER) luminal proteins needed to carry out diverse functions (e.g., protein synthesis and folding, lipid metabolism) is mediated through a carboxy-terminal ER retention sequence (ERS) and its interaction with KDEL receptors. Here, we demonstrate that depleting ER calcium causes mass departure of ERS-containing proteins from cells by overwhelming KDEL receptors. In addition, we provide evidence that KDELR2 and KDELR3, but not KDELR1, are unfolded protein ...[more]