Ontology highlight
ABSTRACT:
SUBMITTER: Correnti CE
PROVIDER: S-EPMC7336869 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Correnti Colin E CE Hallinan Jazmine P JP Doyle Lindsey A LA Ruff Raymond O RO Jaeger-Ruckstuhl Carla A CA Xu Yuexin Y Shen Betty W BW Qu Amanda A Polkinghorn Caley C Friend Della J DJ Bandaranayake Ashok D AD Riddell Stanley R SR Kaiser Brett K BK Stoddard Barry L BL Bradley Philip P
Nature structural & molecular biology 20200323 4
Protein engineering has enabled the design of molecular scaffolds that display a wide variety of sizes, shapes, symmetries and subunit compositions. Symmetric protein-based nanoparticles that display multiple protein domains can exhibit enhanced functional properties due to increased avidity and improved solution behavior and stability. Here we describe the creation and characterization of a computationally designed circular tandem repeat protein (cTRP) composed of 24 identical repeated motifs, ...[more]