Sulfated polymannuroguluronate TGC161 ameliorates leukopenia by inhibiting CD4+ T cell apoptosis.
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ABSTRACT:
SUBMITTER: Shi C
PROVIDER: S-EPMC7336955 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Sulfated polymannuroguluronate TGC161 ameliorates leukopenia by inhibiting CD4<sup>+</sup> T cell apoptosis.
Shi Chuanqin C Han Wenwei W Zhang Meifang M Zang Ruochen R Du Kaixin K Li Li L Xu Ximing X Li Chunxia C Wang Shixin S Qiu Peiju P Guan Huashi H Yang Jinbo J Xiao Shuai S Wang Xin X
Carbohydrate polymers 20200706
Polysaccharides have aroused considerable interest due to their diverse biological activities and low toxicity. In this study, we evaluated the effect of marine polysaccharide sulfated polymannuroguluronate (TGC161) on the leukopenia induced by chemotherapy. It is found that TGC161 ameliorates the leukopenia. Besides, TGC161 would promote CD4<sup>+</sup> T cell differentiation and maturation in the thymus, but does not have a significant effect on precursor cells in bone marrow. Furthermore, TGC ...[more]
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