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Inactivation in the potassium channel KcsA.

ABSTRACT: Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactivation, remains an active area of investigation. Crystallography, computational simulations, and NMR have greatly enriched our understanding of the process. Here we review the major hypotheses regarding C-type inactivation, particularly focusing on the key role played by NMR studies of the prokaryotic potassium channel KcsA, which serves as a good model for voltage gated mammalian channels.

SUBMITTER: Xu Y

PROVIDER: S-EPMC7337057 | biostudies-literature | 2019 Jul-Sep

REPOSITORIES: biostudies-literature

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Inactivation in the potassium channel KcsA.

Xu Yunyao Y McDermott Ann E AE

Journal of structural biology: X 20190612

Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactivation, remains an active area of investigation. Crystallography, computational simulations, and NMR have greatly enriched our understanding of the process. Here we review the major hypotheses regarding C-t ...[more]

PMID: 32647814

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