Ontology highlight
ABSTRACT:
SUBMITTER: Acquaviva L
PROVIDER: S-EPMC7337327 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Acquaviva Laurent L Boekhout Michiel M Karasu Mehmet E ME Brick Kevin K Pratto Florencia F Li Tao T van Overbeek Megan M Kauppi Liisa L Camerini-Otero R Daniel RD Jasin Maria M Keeney Scott S
Nature 20200527 7812
Sex chromosomes in males of most eutherian mammals share only a small homologous segment, the pseudoautosomal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over must occur for correct meiotic segregation<sup>1,2</sup>. How cells ensure that recombination occurs in the PAR is unknown. Here we present a dynamic ultrastructure of the PAR and identify controlling cis- and trans-acting factors that make the PAR the hottest segment for DSB formation in the m ...[more]