Ontology highlight
ABSTRACT:
SUBMITTER: Swaim CD
PROVIDER: S-EPMC7337375 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Swaim Caleb D CD Perng Yi-Chieh YC Zhao Xu X Canadeo Larissa A LA Harastani Houda H HH Darling Tamarand L TL Boon Adrianus C M ACM Lenschow Deborah J DJ Huibregtse Jon M JM
bioRxiv : the preprint server for biology 20200702
A recently emerged betacoronavirus, SARS-CoV-2, has led to a global health crisis that calls for the identification of effective therapeutics for COVID-19 disease. Coronavirus papain-like protease (PLpro) is an attractive drug target as it is essential for viral polyprotein cleavage and for deconjugation of ISG15, an antiviral ubiquitin-like protein. We show here that 6-Thioguanine (6-TG) inhibits SARS-CoV-2 PLpro-catalyzed viral polyprotein cleavage and ISG15 deconjugation in cells and inhibits ...[more]