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Interferon-?-1a Inhibition of Severe Acute Respiratory Syndrome-Coronavirus 2 In Vitro When Administered After Virus Infection.

ABSTRACT: The ongoing coronavirus disease 2019 pandemic has forced the clinical and scientific community to try drug repurposing of existing antiviral agents as a quick option against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Under this scenario, interferon (IFN) ?-1a, whose antiviral potential is already known, and which is a drug currently used in the clinical management of multiple sclerosis, may represent as a potential candidate. In this report, we demonstrate that IFN-?-1a was highly effective in inhibiting in vitro SARS-CoV-2 replication at clinically achievable concentration when administered after virus infection.

SUBMITTER: Clementi N

PROVIDER: S-EPMC7337790 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Interferon-β-1a Inhibition of Severe Acute Respiratory Syndrome-Coronavirus 2 In Vitro When Administered After Virus Infection.

Clementi Nicola N Ferrarese Roberto R Criscuolo Elena E Diotti Roberta Antonia RA Castelli Matteo M Scagnolari Carolina C Burioni Roberto R Antonelli Guido G Clementi Massimo M Mancini Nicasio N

The Journal of infectious diseases 20200801 5

The ongoing coronavirus disease 2019 pandemic has forced the clinical and scientific community to try drug repurposing of existing antiviral agents as a quick option against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Under this scenario, interferon (IFN) β-1a, whose antiviral potential is already known, and which is a drug currently used in the clinical management of multiple sclerosis, may represent as a potential candidate. In this report, we demonstrate that IFN-β-1a was hi ...[more]

PMID: 32559285

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