A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine.
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ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC7338361 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine.
Guo Yanjun Y Rist Pamela M PM Daghlas Iyas I Giulianini Franco F Kurth Tobias T Chasman Daniel I DI
Nature communications 20200706 1
Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (N<sub>cases</sub>/N<sub>controls</sub> = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, r<sub>g</sub> = 0.11, P = 3.56 × 10<sup>-06</sup>) and systolic BP (SBP, r<sub>g</sub> = 0.06, P = 0.01), but not pulse pressure (PP, r<sub>g</s ...[more]
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