Ontology highlight
ABSTRACT:
SUBMITTER: Hammond TC
PROVIDER: S-EPMC7338410 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Hammond Tyler C TC Xing Xin X Wang Chris C Ma David D Nho Kwangsik K Crane Paul K PK Elahi Fanny F Ziegler David A DA Liang Gongbo G Cheng Qiang Q Yanckello Lucille M LM Jacobs Nathan N Lin Ai-Ling AL
Communications biology 20200706 1
Clinical trials focusing on therapeutic candidates that modify β-amyloid (Aβ) have repeatedly failed to treat Alzheimer's disease (AD), suggesting that Aβ may not be the optimal target for treating AD. The evaluation of Aβ, tau, and neurodegenerative (A/T/N) biomarkers has been proposed for classifying AD. However, it remains unclear whether disturbances in each arm of the A/T/N framework contribute equally throughout the progression of AD. Here, using the random forest machine learning method t ...[more]