Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer.

ABSTRACT: The extent and composition of the immune response in a breast cancer is one important prognostic factor for the disease. The aim of the current work was to refine the analysis of the humoral component of an immune response in breast tumors by quantifying mRNA expression of different immunoglobulin classes and study their association with prognosis. We used RNA-Seq data from two local population-based breast cancer cohorts to determine the expression of IGJ and immunoglobulin heavy (IGH) chain-encoding RNAs. The association with prognosis was investigated and public data sets were used to corroborate the findings. Except for IGHE and IGHD, mRNAs encoding heavy chains were generally detected at substantial levels and correlated with other immune-related genes. High IG

SUBMITTER: Larsson C 

PROVIDER: S-EPMC7338507 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature