Intracellular signaling modules linking DNA damage to secretome changes in senescent melanoma cells.

ABSTRACT: Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanocyte and melanoma cell senescence is likely to come into play as a key factor affecting the course of tumorigenesis and responsiveness to therapy; little mechanistic information has been generated, however, that substantiates this idea and facilitates its clinical translation. Here, we established and characterized a model of melanoma cell senescence in which pharmacologically induced DNA damage triggered divergent ATM kinase- and STING-dependent intracellular signaling cascade

SUBMITTER: Chavanet A 

PROVIDER: S-EPMC7338598 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature