Ontology highlight
ABSTRACT:
SUBMITTER: Zhao M
PROVIDER: S-EPMC7338762 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhao Mingyue M Wang Dennis Ding-Hwa DD Liu Xiaojing X Tian Rong R
Frontiers in physiology 20200630
Macrophages are key components of innate immunity, and they play critical roles in heart health and diseases. Following acute myocardial infarction (MI), infiltrating macrophages undergo drastic phenotypic transition from pro-inflammatory in the early stage to pro-healing in the late stage. Transcriptome analyses of macrophage in the infarct zone show a time-dependent reprogramming of mitochondrial and metabolic functions, which parallels the changes of macrophage function. These observations su ...[more]