Inflammation suppression prevents tumor cell proliferation in a mouse model of thyroid cancer.

ABSTRACT: The incidence of thyroid cancer, the most frequent endocrine neoplasia, is rapidly increasing. Significant progress has recently been made in the identification of genetic lesions in thyroid cancer; however, whether inflammation contributes to thyroid cancer progression remains unknown. Using a mouse model of aggressive follicular thyroid cancer (FTC; Thrb^PV/PVPten^+/- mice), we aimed to elucidate a cause-effect relationship at the molecular level. The Thrb^PV/PVPten^+/- mouse expresses a dominantly negative thyroid hormone receptor β (denoted as PV) and a deletion of a single allele of the Pten gene. These two oncogenic signaling pathways synergistically activate PI3K-AKT signaling to drive cancer progression as in human FTC. A

SUBMITTER: Park S 

PROVIDER: S-EPMC7339265 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature