Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman LM
PROVIDER: S-EPMC7339881 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Hoffman Lindsey M LM Richardson Elizabeth Anne EA Ho Ben B Margol Ashley A Reddy Alyssa A Lafay-Cousin Lucie L Chi Susan S Slavc Irene I Judkins Alexander A Hasselblatt Martin M Bourdeaut Franck F Frühwald Michael C MC Vibhakar Rajeev R Bouffet Eric E Huang Annie A
Neuro-oncology 20200701 7
Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant central nervous system cancer arising in infants and younger children, historically considered to be homogeneous, monogenic, and incurable. Recent use of intensified therapies has modestly improved survival for ATRT; however, a majority of patients will still succumb to their disease. While ATRTs almost universally exhibit loss of SMARCB1 (BAF47/INI1/SNF5), recent whole genome, transcriptome, and epigenomic analyses of large coh ...[more]