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Surfactant-based prophylaxis and therapy against COVID-19: A possibility.


ABSTRACT: Hand hygiene by washing with soap and water is recommended for the prevention of COVID-19 spread. Soaps and detergents are explained to act by damaging viral spike glycoproteins (peplomers) or by washing out the virus through entrapment in the micelles. Technically, soaps come under a functional category of molecules known as surfactants. Surfactants are widely used in pharmaceutical formulations as excipients. We wonder why surfactants are still not tried for prophylaxis or therapy against COVID-19? That too when many of them have proven antiviral properties. Moreover, lung surfactants have already shown benefits in respiratory viral infections. Therefore, we postulate that surfactant-based prophylaxis and therapy would be promising. We believe that our hypothesis would stimulate debate or new research exploring the possibility of surfactant-based prophylaxis and therapy against COVID-19. The success of a surfactant-based technique would save the world from any such pandemic in the future too.

SUBMITTER: Pramod K 

PROVIDER: S-EPMC7340033 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Surfactant-based prophylaxis and therapy against COVID-19: A possibility.

Pramod K K   Kotta Sabna S   Jijith U S US   Aravind A A   Abu Tahir M M   Manju C S CS   Gangadharappa H V HV  

Medical hypotheses 20200707


Hand hygiene by washing with soap and water is recommended for the prevention of COVID-19 spread. Soaps and detergents are explained to act by damaging viral spike glycoproteins (peplomers) or by washing out the virus through entrapment in the micelles. Technically, soaps come under a functional category of molecules known as surfactants. Surfactants are widely used in pharmaceutical formulations as excipients. We wonder why surfactants are still not tried for prophylaxis or therapy against COVI  ...[more]

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