Ontology highlight
ABSTRACT:
SUBMITTER: Jordan MB
PROVIDER: S-EPMC7340087 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Jordan Michael B MB Allen Carl E CE Greenberg Jay J Henry Michael M Hermiston Michelle L ML Kumar Ashish A Hines Melissa M Eckstein Olive O Ladisch Stephan S Nichols Kim E KE Rodriguez-Galindo Carlos C Wistinghausen Birte B McClain Kenneth L KL
Pediatric blood & cancer 20190724 11
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation, often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive constellation of features has been described for HLH, diagnosis remains challenging as patients have diverse presentations associated with a variety of triggers. We propose two concepts to clarify how HLH is diagnosed and treated: within the broader syndrome of HLH, "HLH disease" should be distinguished from "HLH disease mi ...[more]