Ontology highlight
ABSTRACT:
SUBMITTER: Azad TD
PROVIDER: S-EPMC7340556 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Azad Tej D TD Jin Michael C MC Bernhardt Lydia J LJ Bettegowda Chetan C
Neurosurgical focus 20200101 1
Diffuse midline glioma (DMG) is a highly malignant childhood tumor with an exceedingly poor prognosis and limited treatment options. The majority of these tumors harbor somatic mutations in genes encoding histone variants. These recurrent mutations correlate with treatment response and are forming the basis for molecularly guided clinical trials. The ability to detect these mutations, either in circulating tumor DNA (ctDNA) or cerebrospinal fluid tumor DNA (CSF-tDNA), may enable noninvasive mole ...[more]