Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes.
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ABSTRACT:
SUBMITTER: Zhang PA
PROVIDER: S-EPMC7340685 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes.
Zhang Ping-An PA Sun Qian Q Li Yong-Chang YC Weng Rui-Xia RX Wu Rui R Zhang Hong-Hong HH Xu Guang-Yin GY
Neuroscience bulletin 20200320 7
Purinergic receptors have been reported to be involved in brain disorders. In this study, we explored their roles and mechanisms underlying the memory impairment in rats with type 2 diabetes mellitus (T2DM). T2DM rats exhibited a worse performance in the T-maze and Morris water maze (MWM) than controls. Microglia positive for P2X purinoceptor 4 (P2X4R) in the hippocampus were reduced and activated microglia were increased in T2DM rats. Long Amplicon PCR (LA-PCR) showed that DNA amplification of ...[more]
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