Ontology highlight
ABSTRACT:
SUBMITTER: Huda MN
PROVIDER: S-EPMC7341122 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Huda M Nazmul MN VerHague Melissa M Albright Jody J Smallwood Tangi T Bell Timothy A TA Que Excel E Miller Darla R DR Roshanravan Baback B Allayee Hooman H Manuel de Villena Fernando Pardo FP Bennett Brian J BJ
G3 (Bethesda, Md.) 20200707 7
Plasma concentration of Cystatin C (CysC) level is a biomarker of glomerular filtration rate in the kidney. We use a Systems Genetics approach to investigate the genetic determinants of plasma CysC concentration. To do so we perform Quantitative Trait Loci (QTL) and expression QTL (eQTL) analysis of 120 Diversity Outbred (DO) female mice, 56 weeks of age. We performed network analysis of kidney gene expression to determine if the gene modules with common functions are associated with kidney biom ...[more]