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Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management.

ABSTRACT: We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.

SUBMITTER: Santana MF 

PROVIDER: S-EPMC7341831 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management.

Santana Monique Freire MF   Pivoto Guilherme G   Alexandre Márcia A Araujo MAA   Baía-da-Silva Djane Clarys DC   Borba Mayla Gabriela da Silva MGDS   Val Fernando Almeida FA   Brito-Sousa Jose Diego JD   Melo Gisely Cardoso GC   Monteiro Wuelton Marcelo WM   Souza João Vicente Braga JVB   Pinheiro Silviane Bezerra SB   Ferreira Luiz Carlos Lima LCL   Naveca Felipe Gomes FG   Nascimento Valdinete Alves VA   Corado André Lima Guerra ALG   Hajjar Ludhmila Abrahão LA   Silva Neto João Ricardo JR   Siva George Alan Villarouco GAV   Pasqualotto Alessandro C AC   Lacerda Marcus Vinícius Guimarães MVG  

Revista da Sociedade Brasileira de Medicina Tropical 20200703

We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IP  ...[more]

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