Ontology highlight
ABSTRACT:
SUBMITTER: Shanmugasundaram M
PROVIDER: S-EPMC7341905 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Shanmugasundaram Maruda M Kurouski Dmitry D Wan William W Stubbs Gerald G Dukor Rina K RK Nafie Laurence A LA Lednev Igor K IK
The journal of physical chemistry. B 20150626 27
Amyloid fibril polymorphism is not well understood despite its potential importance for biological activity and associated toxicity. Controlling the polymorphism of mature fibrils including their morphology and supramolecular chirality by postfibrillation changes in the local environment is the subject of this study. Specifically, the effect of pH on the stability and dynamics of HET-s (218-289) prion fibrils has been determined through the use of vibrational circular dichroism (VCD), deep UV re ...[more]