Effects of G-protein mutations on skin color.
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ABSTRACT:
SUBMITTER: Van Raamsdonk CD
PROVIDER: S-EPMC7341985 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Publications
Effects of G-protein mutations on skin color.
Van Raamsdonk Catherine D CD Fitch Karen R KR Fuchs Helmut H de Angelis Martin Hrabé MH Barsh Gregory S GS
Nature genetics 20040822 9
A new class of dominant dark skin (Dsk) mutations discovered in a screen of approximately 30,000 mice is caused by increased dermal melanin. We identified three of four such mutations as hypermorphic alleles of Gnaq and Gna11, which encode widely expressed Galphaq subunits, act in an additive and quantitative manner, and require Ednrb. Interactions between Gq and Kit receptor tyrosine kinase signaling can mediate coordinate or independent control of skin and hair color. Our results provide a mec ...[more]
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