Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.

ABSTRACT: Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. Here, we provide evidence that small extracellular vesicles (sEVs) isolated from primary fibroblasts of young human donors ameliorate certain biomarkers of senescence in cells derived from old and Hutchinson-Gilford progeria syndrome donors. Importantly, sEVs from young cells ameliorate senescence in a variety of tissues in old mice. Mechanistically, we identified sEVs to have intrinsic glutathione-S-transferase activity partially due to the high levels of expression of the glutathione-related protein (GSTM2). Transfection of recombinant GSTM2 into sEVs derived from old fibroblast

SUBMITTER: Fafian-Labora JA 

PROVIDER: S-EPMC7342013 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature