Assessing the Causal Effects of Human Serum Metabolites on 5 Major Psychiatric Disorders.

ABSTRACT: Psychiatric disorders are the leading cause of disability worldwide while the pathogenesis remains unclear. Genome-wide association studies (GWASs) have made great achievements in detecting disease-related genetic variants. However, functional information on the underlying biological processes is often lacking. Current reports propose the use of metabolic traits as functional intermediate phenotypes (the so-called genetically determined metabotypes or GDMs) to reveal the biological mechanisms of genetics in human diseases. Here we conducted a two-sample Mendelian randomization analysis that uses GDMs to assess the causal effects of 486 human serum metabolites on 5 major psychiatric disorders, which respectively were schizophrenia (SCZ), major depression (MDD), bipolar disorder (BIP), autis

SUBMITTER: Yang J 

PROVIDER: S-EPMC7342080 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature