Ontology highlight
ABSTRACT:
SUBMITTER: Umviligihozo G
PROVIDER: S-EPMC7343213 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Umviligihozo Gisele G Cobarrubias Kyle D KD Chandrarathna Sandali S Jin Steven W SW Reddy Nicole N Byakwaga Helen H Muzoora Conrad C Bwana Mwebesa B MB Lee Guinevere Q GQ Hunt Peter W PW Martin Jeff N JN Brumme Chanson J CJ Bangsberg David R DR Karita Etienne E Allen Susan S Hunter Eric E Ndung'u Thumbi T Brumme Zabrina L ZL Brockman Mark A MA
Journal of virology 20200701 14
Downregulation of BST-2/tetherin and CD4 by HIV-1 viral protein U (Vpu) promotes viral egress and allows infected cells to evade host immunity. Little is known however about the natural variability in these Vpu functions among the genetically diverse viral subtypes that contribute to the HIV-1 pandemic. We collected Vpu isolates from 332 treatment-naive individuals living with chronic HIV-1 infection in Uganda, Rwanda, South Africa, and Canada. Together, these Vpu isolates represent four major H ...[more]