Ontology highlight
ABSTRACT:
SUBMITTER: Lee PC
PROVIDER: S-EPMC7343393 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Lee Pei-Chung PC Machner Matthias P MP
Cell host & microbe 20180901 3
The intracellular pathogen Legionella pneumophila encodes translocated effector proteins that modify host cell processes to support bacterial survival and growth. Here, we show that the L. pneumophila effector protein LegK7 hijacks the conserved Hippo signaling pathway by molecularly mimicking host Hippo kinase (MST1 in mammals), which is the key regulator of pathway activation. LegK7, like Hippo/MST1, phosphorylates the scaffolding protein MOB1, which triggers a signaling cascade resulting in t ...[more]