Ontology highlight
ABSTRACT:
SUBMITTER: Alcalde-Estevez E
PROVIDER: S-EPMC7343454 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Alcalde-Estévez Elena E Asenjo-Bueno Ana A Sosa Patricia P Olmos Gemma G Plaza Patricia P Caballero-Mora María Ángeles MÁ Rodríguez-Puyol Diego D Ruíz-Torres María Piedad MP López-Ongil Susana S
Aging 20200622 12
Endothelial dysfunction, with increased endothelin-1 (ET-1) synthesis, and sarcopenia, characterized by the loss of muscular mass and strength, are two aging-related conditions. However, a relationship between them has not been already established. The aim of this study was to determine whether ET-1 induces senescence and fibrosis in cultured murine myoblasts, which could be involved in the development of sarcopenia related to aging. For this purpose, myoblasts were incubated with ET-1 to assess ...[more]