Ontology highlight
ABSTRACT:
SUBMITTER: Montali A
PROVIDER: S-EPMC7344559 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Montali Aurora A Berini Francesca F Brivio Maurizio Francesco MF Mastore Maristella M Saviane Alessio A Cappellozza Silvia S Marinelli Flavia F Tettamanti Gianluca G
Antibiotics (Basel, Switzerland) 20200604 6
Glycopeptide antibiotics (GPAs) are drugs of last resort for treating infections by Gram-positive bacteria. They inhibit bacterial cell wall assembly by binding to the d-Ala-d-Ala terminus of peptidoglycan precursors, leading to cell lysis<b>.</b> Vancomycin and teicoplanin are first generation GPAs, while dalbavancin is one of the few, recently approved, second generation GPAs. In this paper, we developed an in vivo insect model to compare, for the first time, the efficacy of these three GPAs i ...[more]