Pyruvate affects inflammatory responses of macrophages during influenza A virus infection.
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ABSTRACT:
SUBMITTER: Abusalamah H
PROVIDER: S-EPMC7345311 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Pyruvate affects inflammatory responses of macrophages during influenza A virus infection.
Abusalamah Hazar H Reel Jessica M JM Lupfer Christopher R CR
Virus research 20200704
Pyruvate is the end product of glycolysis and transported into the mitochondria for use in the tricarboxylic acid (TCA) cycle. It is also a common additive in cell culture media. We discovered that inclusion of sodium pyruvate in culture media during infection of mouse bone marrow derived macrophages with influenza A virus impaired cytokine production (IL-6, IL-1β, and TNF-α). Sodium pyruvate did not inhibit viral RNA replication. Instead, the addition of sodium pyruvate alters cellular metaboli ...[more]
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