Systematic Identification of lncRNA-Associated ceRNA Networks in Immune Thrombocytopenia.
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ABSTRACT:
SUBMITTER: Fan Z
PROVIDER: S-EPMC7345964 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Systematic Identification of lncRNA-Associated ceRNA Networks in Immune Thrombocytopenia.
Fan Zhenwei Z Wang Xuan X Li Peng P Mei Chunli C Zhang Min M Zhao Chunshan C Song Yan Y
Computational and mathematical methods in medicine 20200630
Primary immune thrombocytopenia (ITP) is an autoimmune disease. However, the molecular mechanisms underlying ITP remained to be further investigated. In the present study, we analyzed a series of public datasets (including GSE43177 and GSE43178) and identified 468 upregulated mRNAs, 272 downregulated mRNAs, 134 upregulated lncRNAs, 23 downregulated lncRNAs, 29 upregulated miRNAs, and 39 downregulated miRNAs in ITP patients. Then, we constructed protein-protein interaction networks, miRNA-mRNA an ...[more]
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