Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC7346054 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Chen Chao C Wei Yongyue Y Wei Liangmin L Chen Jiajin J Chen Xin X Dong Xuesi X He Jieyu J Lin Lijuan L Zhu Ying Y Huang Hui H You Dongfang D Lai Linjing L Shen Sipeng S Duan Weiwei W Su Li L Shafer Andrea A Fleischer Thomas T Bjaanæs Maria Moksnes MM Karlsson Anna A Planck Maria M Wang Rui R Staaf Johan J Helland Åslaug Å Esteller Manel M Zhang Ruyang R Chen Feng F Christiani David C DC
Aging 20200608 11
DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We performed a methylation-age interaction analysis using 1,230 early-stage lung adenocarcinoma patients from five cohorts. A Cox proportional hazards model was used to investigate lung adenocarcinoma and squamous cell carcinoma patients for methylation-age interactions, which were fur ...[more]