Unknown

Dataset Information

0

LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK.

ABSTRACT: Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cell proliferation and cell migration were identified using RNA-sequence. Subsequently, it was confirmed that LINC01419 binds to EZH2, leading to histone methylation of the RECK promoter. Interaction between LINC01419 and FUS stabilized EZH2 mRNA thereby enhancing EZH2 expression. Conclusively, the results of this study confirm that LINC01419 may serve as a potential target for HCC diagnosis and treatment.

SUBMITTER: Zhang G 

PROVIDER: S-EPMC7346057 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK.

Zhang Gong G   Chen Ximin X   Ma Lei L   Ding Rui R   Zhao Lihong L   Ma Feng F   Deng Xubin X  

Aging 20200610 11

Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. <i>In vitro</i> study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cell proliferation and cell migration were identified using RNA-sequence. Subsequently, it was confirmed that LINC01419 binds to EZH2, leading to histone methylation of the RECK  ...[more]

Similar Datasets

Transcriptomics RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1
2023-12-20 | GSE248064 | GEO
Genomics RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1 [ChIP-Seq]
2023-12-20 | GSE248063 | GEO
Transcriptomics RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1 [RNA-Seq]
2023-12-20 | GSE248062 | GEO
Unknown CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NF?B pathway in hepatocellular carcinoma.
| S-EPMC7205899 | biostudies-literature
Unknown Upregulated hsa_circ_0005785 Facilitates Cell Growth and Metastasis of Hepatocellular Carcinoma Through the miR-578/APRIL Axis.
| S-EPMC7466587 | biostudies-literature
Unknown FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2.
| S-EPMC4148126 | biostudies-literature
Unknown Circular RNA circ-ADD3 inhibits hepatocellular carcinoma metastasis through facilitating EZH2 degradation via CDK1-mediated ubiquitination.
| S-EPMC6726993 | biostudies-literature
Unknown DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/?-catenin pathway.
| S-EPMC5986742 | biostudies-literature
Unknown EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma.
| S-EPMC6748116 | biostudies-literature
Unknown POU2F1 promotes growth and metastasis of hepatocellular carcinoma through the FAT1 signaling pathway.
| S-EPMC5574939 | biostudies-literature