Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms.
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ABSTRACT:
SUBMITTER: Fransquet PD
PROVIDER: S-EPMC7346866 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms.
Fransquet Peter Daniel PD Lacaze Paul P Saffery Richard R Phung James J Parker Emily E Shah Raj R Murray Anne A Woods Robyn L RL Ryan Joanne J
Alzheimer's & dementia (Amsterdam, Netherlands) 20200709 1
<h4>Introduction</h4>This study determined whether blood DNA methylation (DNAm) patterns differentiate individuals with presymptomatic dementia compared to controls.<h4>Methods</h4>DNAm was measured in 73 individuals prior to dementia diagnosis and 87 cognitively healthy controls matched for age, sex, smoking, education, and baseline cognition. DNAm was also measured at 3 years follow-up in 25 dementia cases, and 24 controls.<h4>Results</h4>Cases and controls differed in DNAm (unadjusted <i>P</i ...[more]
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