Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC7346970 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Chen Changliang C Gupta Prachi P Parashar Deepak D Nair Gopakumar G GG George Jasmine J Geethadevi Anjali A Wang Wei W Tsaih Shirng-Wern SW Bradley William W Ramchandran Ramani R Rader Janet S JS Chaluvally-Raghavan Pradeep P Pradeep Sunila S
Oncogene 20200206 14
High-grade serous carcinoma, accounts for up to 70% of all ovarian cases. Furin, a proprotein convertase, is highly expressed in high-grade serous carcinoma of ovarian cancer patients, and its expression is even higher in tumor omentum than in normal omentum, the preferred site of ovarian cancer metastasis. The proteolytic actions of this cellular endoprotease help the maturation of several important precursors of protein substrates and its levels increase the risk of several cancer. We show tha ...[more]