Unknown

Dataset Information

0

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function.


ABSTRACT: PURPOSE:It is difficult to assess airway obstruction using spirometry in adult asthmatic patients with preserved lung function. Impulse oscillometry (IOS) can detect not only airway resistance but also reactance. Therefore, IOS may be useful in assessing pulmonary function in such patients. We investigated the applicability of IOS for asthma patients with preserved lung function. METHODS:Between 2015 and 2018, 1,248 adult asthmatic patients suspected of having asthma who visited the Allergy and Asthma Center of Severance Hospital underwent both spirometry and IOS. Consequently, 784 patients had asthma, 111 had chronic obstructive lung disease (COPD) or asthma-COPD overlap, and 7 had parenchymal lung disease. The remaining 346 patients had chronic cough without underlying lung or airway disease. Among the 784 asthmatic patients, 191 with decreased lung function (predicted forced expiratory volume in 1 second [FEV1] < 80%) were excluded. Propensity score matching was performed to adjust baseline characteristics between 346 non-asthmatic and 593 asthmatic patients with preserved lung function. Subsequently, we compared the spirometry and IOS parameters between the 329 asthmatic and 329 non-asthmatic patients. RESULTS:Multiple logistic regression analysis showed that the area of reactance (AX) was associated with asthma with preserved lung function. In receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) of AX (AUC = 0.6823) for asthma was not significantly different from that of FEV1 (AUC = 0.6758). However, the AUC of a combination of AX and FEV1 (AUC = 0.7437) for asthma was significantly higher than that of FEV1 alone. The cutoff value of AX was 0.51 kPa/L in univariate ROC analysis. CONCLUSIONS:AX is associated with adult asthma with preserved lung function. Performing spirometry together with IOS is more beneficial than performing spirometry alone for diagnosing asthma in adult patients with preserved lung function.

SUBMITTER: Kim SR 

PROVIDER: S-EPMC7346993 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function.

Kim Sung Ryeol SR   Park Kyung Hee KH   Son Nak Hoon NH   Moon Jinyeong J   Park Hye Jung HJ   Kim Kyungchul K   Park Jung Won JW   Lee Jae Hyun JH  

Allergy, asthma & immunology research 20200901 5


<h4>Purpose</h4>It is difficult to assess airway obstruction using spirometry in adult asthmatic patients with preserved lung function. Impulse oscillometry (IOS) can detect not only airway resistance but also reactance. Therefore, IOS may be useful in assessing pulmonary function in such patients. We investigated the applicability of IOS for asthma patients with preserved lung function.<h4>Methods</h4>Between 2015 and 2018, 1,248 adult asthmatic patients suspected of having asthma who visited t  ...[more]

Similar Datasets

| S-EPMC9574560 | biostudies-literature
| S-EPMC10485984 | biostudies-literature
| S-EPMC3191594 | biostudies-literature
| S-EPMC4830384 | biostudies-literature
| S-EPMC7553116 | biostudies-literature
| S-EPMC6794106 | biostudies-literature
| S-EPMC10160799 | biostudies-literature
| S-EPMC4683718 | biostudies-literature
| S-EPMC8264702 | biostudies-literature
| S-EPMC7573225 | biostudies-literature