Neuroendocrine tumours and their microenvironment.
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ABSTRACT:
SUBMITTER: de Hosson LD
PROVIDER: S-EPMC7347684 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Neuroendocrine tumours and their microenvironment.
de Hosson Lotte D LD Takkenkamp Tim J TJ Kats-Ugurlu Gursah G Bouma Grietje G Bulthuis Marian M de Vries Elisabeth G E EGE van Faassen Martijn M Kema Ido P IP Walenkamp Annemiek M E AME
Cancer immunology, immunotherapy : CII 20200408 8
Tumours can escape the immune system by expressing programmed death-ligand-1 (PD-L1), which allows them to bind to PD-1 on T-cells and avoid recognition by the immune system. Regulatory T-cells (Tregs), indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) also play a role in immune suppression. Knowledge about the interaction of neuroendocrine tumours (NETs) with their immune microenvironment and the role of immunotherapy in patients with NET is scarce. Here, we investigated th ...[more]
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