Pilot study of neurologic toxicity in mice after proton minibeam therapy.
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ABSTRACT:
SUBMITTER: Eley JG
PROVIDER: S-EPMC7347840 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Pilot study of neurologic toxicity in mice after proton minibeam therapy.
Eley John G JG Chadha Awalpreet S AS Quini Caio C Vichaya Elisabeth G EG Zhang Cancan C Davis James J Sahoo Narayan N Waddell Jaylyn J Leiser Dominic D Dilmanian F Avraham FA Krishnan Sunil S
Scientific reports 20200709 1
Proton minibeams (MBs) comprised of parallel planar beamlets were evaluated for their ability to spare healthy brain compared to proton broad beams (BBs). Juvenile mice were given partial brain irradiation of 10 or 30 Gy integral dose using 100 MeV protons configured either as BBs or arrays of 0.3-mm planar MBs spaced 1.0 mm apart on center. Neurologic toxicity was evaluated during an 8-month surveillance: no overt constitutional or neurologic dysfunction was noted for any study animals. Less ac ...[more]
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