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Sera of elderly obstructive sleep apnea patients alter blood-brain barrier integrity in vitro: a pilot study.

ABSTRACT: Obstructive sleep apnea syndrome (OSAS) is characterized by repeated episodes of hypoxia during the night. The severity of the disorder can be evaluated using an apnea-hypopnea index (AHI). The physiological consequences are mainly cardiovascular and neuronal dysfunctions. One hypothesis to explain such associated neurological disorders is disruption of the blood-brain barrier (BBB), which protects the brain from endovascular cytotoxic compounds. We selected two subgroups of volunteers from the PROOF cohort study (France), a group of patients suffering newly diagnosed severe OSAS (AHI?>?30/h) and a group showing no sleep apnea (AHI?

SUBMITTER: Voirin AC

PROVIDER: S-EPMC7347951 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Sera of elderly obstructive sleep apnea patients alter blood-brain barrier integrity in vitro: a pilot study.

Voirin Anne-Cloé AC Celle Sébastien S Perek Nathalie N Roche Frédéric F

Scientific reports 20200709 1

Obstructive sleep apnea syndrome (OSAS) is characterized by repeated episodes of hypoxia during the night. The severity of the disorder can be evaluated using an apnea-hypopnea index (AHI). The physiological consequences are mainly cardiovascular and neuronal dysfunctions. One hypothesis to explain such associated neurological disorders is disruption of the blood-brain barrier (BBB), which protects the brain from endovascular cytotoxic compounds. We selected two subgroups of volunteers from the ...[more]

PMID: 32647186

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