Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC7348002 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wang Tianming T Wei Qinjun Q Liang Lihong L Tang Xujun X Yao Jun J Lu Yajie Y Qu Yuan Y Chen Zhibin Z Xing Guangqian G Cao Xin X
iScience 20200620 7
The accumulation of giant lipid droplets (LDs) increases the risk of metabolic disorders including obesity and insulin resistance. The lipolysis process involves the activation and transfer of lipase, but the molecular mechanism is not completely understood. The translocation of ATGL, a critical lipolysis lipase, from the ER to the LD surface is mediated by an energy catabolism complex. Oxysterol-binding protein-like 2 (OSBPL2/ORP2) is one of the lipid transfer proteins that regulates intracellu ...[more]